Tranquilization and sedation medications are given to calm an animal under various conditions, usually physically or mentally stressful situations. The animal remains awake or may “sleep” but is easily aroused when stimulated. Pet owners frequently request tranquilizers for their animals during travel, thunderstorms and fireworks, among others. Sedation and tranquilization are not without risk, and there are a wide variety of available medications. We recommend that each animal be assessed as thoroughly as possible prior to dispensing these medications.